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September 15, 2017International Journal of Molecular SciencesOpen Access

The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side

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Population

Patients with essential hypertension and preclinical models of hypertension

Design

Review

Authors

GTGabriele TogliattoGLGiusy LombardoMBMaria Felice Brizzi

Discussion

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Overview

Does not support redox therapies in hypertension yet; leaves open targeted mechanistic and clinical validation.

Structured PICO

P
Population
Patients with essential hypertension and preclinical models of hypertension
I
Intervention
Antioxidant approaches and interventions interfering with reactive oxygen species (ROS) production

This review highlights the discrepancy between preclinical and human data regarding the role of oxidative stress in essential hypertension and discusses potential antioxidant therapeutic strategies.

Cite This Study

Togliatto et al. (2017) studied this question.

synapsesocial.com/papers/6a72b594febe604dd70abb87https://doi.org/10.3390/ijms18091988
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension2004 · 869 citations
  2. 2Reactive oxygen species in hypertension*1An update2004 · 343 citations
  3. 3Oxidative Stress and Antioxidants in Hypertension: A Review onMechanisms and Clinical Challenges2026
  4. 4Oxidative Stress and Antioxidants in Hypertension–A Current Review2015 · 353 citations
  5. 5Oxidative Stress: A Unifying Paradigm in Hypertension2020 · 268 citations