Key result
Reactive oxygen species contribute to the development of hypertension by inducing vascular contraction, endothelial dysfunction, hypertrophic remodeling, and renal tissue damage.
Understanding the mechanisms of ROS formation and their pathophysiologic effects in hypertension may lead to novel specific antihypertensive treatments.
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ROS pathways should not alter current hypertension management; extends mechanistic data but leaves open targeted therapies.
Bernard Lassègue (2004) conducted a review in Hypertension. Reactive oxygen species (ROS) was evaluated. Reactive oxygen species contribute to the development of hypertension by inducing vascular contraction, endothelial dysfunction, hypertrophic remodeling, and renal tissue damage.
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