Key result
Serum uric acid levels > 6.0 mg/dL independently predicted left ventricular diastolic dysfunction in patients with chronic kidney disease (OR 14.3).
Why the study?
Is hyperuricemia an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic kidney disease?
Population
50 patients with chronic kidney disease (CKD), stages 2-5
Comparison
Hyperuricemia (serum uric acid > 6.0 mg/dL) vs Normal serum uric acid (≤ 6.0 mg/dL)
Design
Cross-sectional
Authors
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Should not yet guide uric acid management in CKD; leaves open a causal role in diastolic dysfunction.
Cross-Sectional (n=50)
No
Is hyperuricemia an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic kidney disease?
Odds Ratio: 14.3 (95% CI 2–103.2)
p-value: p=0.006
Elevated serum uric acid (>6.0 mg/dL) is strongly associated with left ventricular diastolic dysfunction in patients with chronic kidney disease.
Gromadziński et al. (2015) conducted a cross-sectional in Chronic Kidney Disease (n=50). Serum uric acid > 6.0 mg/dL vs. Serum uric acid ≤ 6.0 mg/dL was evaluated on Left ventricular diastolic dysfunction (EmLV < 8 cm/s) (OR 14.3, 95% CI 2.0-103.2, p=0.006). Serum uric acid levels > 6.0 mg/dL independently predicted left ventricular diastolic dysfunction in patients with chronic kidney disease (OR 14.3).
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