Key result
High serum uric acid is linked to LVDD progression in apparently healthy subjects.
Why the study?
Cardiometabolic risk factors play critical roles in LVDD, but the relation between serum uric acid levels and LVDD progression in apparently healthy subjects was unclear.
Is higher serum uric acid associated with the progression of left ventricular diastolic dysfunction in apparently healthy subjects?
Cohort (n=1,082)
Is higher serum uric acid associated with the progression of left ventricular diastolic dysfunction in apparently healthy subjects?
High serum uric acid levels are associated with the progression of left ventricular diastolic dysfunction in healthy individuals, suggesting a potential role in early HFpEF pathogenesis.
May support uric acid monitoring for early LVDD risk stratification; leaves open causal effects and need for intervention trials.
Background: Left ventricular (LV) diastolic dysfunction (LVDD) is the defining feature of heart failure with preserved ejection fraction (HFpEF) and predicts subsequent incident heart failure (HF) and all-cause mortality. Mounting evidence reveals that cardiometabolic risk factors play critical roles in the development of LVDD. In this study, we sought to investigate the relation between serum uric acid (SUA) level and the progression of LVDD in apparently healthy patients. Methods: A total of 1082 apparently healthy subjects without diagnosed cardiovascular disease and LVDD were consecutively enrolled. SUA levels were measured, and repeat echocardiography and tissue Doppler imaging (TDI) were performed at baseline and during 1-year follow-up. Results: mol/L SUA). Subgroup analysis suggested that the association between SUA and LVDD development was more pronounced in subjects without other cardiometabolic risk factors involved. Factor analysis demonstrated that high SUA was the major cardiometabolic attribute in patients with LVDD progression. Conclusion: Our findings suggest that high SUA is an independent cardiometabolic risk factor for the progression of LVDD in apparently healthy subjects.
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Yang et al. (2022) conducted a cohort in Apparently healthy subjects (n=1,082). Serum uric acid (SUA) was evaluated on Progression of left ventricular diastolic dysfunction (LVDD). High serum uric acid is an independent cardiometabolic risk factor for the progression of left ventricular diastolic dysfunction in apparently healthy subjects.
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