Key result
Among cardiac patients with preserved ejection fraction, higher serum uric acid levels were significantly associated with diastolic dysfunction in women (OR 8.06, P<0.001) but not in men.
Why the study?
Is higher serum uric acid associated with cardiac diastolic dysfunction in patients with preserved ejection fraction?
Population
744 cardiac patients (202 women and 542 men) with preserved left ventricular ejection fraction
Comparison
Higher serum uric acid levels vs Lower serum uric acid levels
Design
Cross-sectional
Authors
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Hypothesis-generating for sex-specific uric acid effects on diastolic function; prospective trials needed before clinical adoption.
Cross-Sectional (n=744)
Is higher serum uric acid associated with cardiac diastolic dysfunction in patients with preserved ejection fraction?
Odds Ratio: 8.06
p-value: p=<0.001
Higher serum uric acid levels are strongly associated with the presence of diastolic dysfunction in women with preserved ejection fraction, but not in men.
Nogi et al. (2015) conducted a cross-sectional in Cardiac patients with preserved left ventricular ejection fraction (n=744). Serum uric acid vs. Lowest serum uric acid quartile was evaluated on Diastolic dysfunction (OR 8.06, p=<0.001). Among cardiac patients with preserved ejection fraction, higher serum uric acid levels were significantly associated with diastolic dysfunction in women (OR 8.06, P<0.001) but not in men.
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