What question did this study set out to answer?

The aim is to explore the relationship between adiponectin levels and insulin sensitivity in essential hypertension and the impact of RAS blockade.

June 10, 2003HypertensionOpen Access

Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Essential hypertension (n=50). Intervention: Renin-angiotensin system blockade (temocapril or candesartan) vs. Normotensive controls and baseline values. Primary outcome: Adiponectin concentrations and insulin sensitivity (M value).

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Key result

Renin-angiotensin system blockade for 2 weeks significantly increased adiponectin concentrations and improved insulin sensitivity in patients with essential hypertension.

Why the study?

Does renin-angiotensin system blockade increase adiponectin concentrations and improve insulin sensitivity in patients with essential hypertension?

Key Points

The aim is to explore the relationship between adiponectin levels and insulin sensitivity in essential hypertension and the impact of RAS blockade.
Analyzed 30 essential hypertensives and 20 normotensives using euglycemic-hyperinsulinemic clamp.
Divided hypertensives into insulin-resistant and non-insulin-resistant groups based on M values.
Administered RAS blockers (temocapril or candesartan) for 2 weeks to assess changes in adiponectin.
Adiponectin concentrations increased significantly post-treatment with temocapril or candesartan.
EHT-R had lower adiponectin and higher insulin levels compared to normotensives.
Treatment improved insulin sensitivity (M value) without affecting BMI and HDL cholesterol.

Study Design

Type

Observational (n=50)

Structured PICO

Does renin-angiotensin system blockade increase adiponectin concentrations and improve insulin sensitivity in patients with essential hypertension?

Population

50 participants (30 with essential hypertension and 20 normotensive controls), with a subset of 16 hypertensive patients treated with RAS blockade for 2 weeks.

Exposure

Temocapril 4 mg/d (n=9) or candesartan 8 mg/d (n=7) for 2 weeks

Outcome

Adiponectin concentrations and insulin sensitivity (M value evaluated by euglycemic-hyperinsulinemic glucose clamp)surrogate

Blockade of the renin-angiotensin system with ACE inhibitors or ARBs increases adiponectin levels and improves insulin sensitivity in patients with essential hypertension.

Discussion

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Implication

Lower adiponectin links to insulin resistance in hypertension; leaves open whether RAS blockade improves metabolic outcomes.

Cite This Study

Furuhashi et al. (2003) conducted an observational in Essential hypertension (n=50). Renin-angiotensin system blockade (temocapril or candesartan) vs. Normotensive controls and baseline values was evaluated on Adiponectin concentrations and insulin sensitivity (M value). Renin-angiotensin system blockade for 2 weeks significantly increased adiponectin concentrations and improved insulin sensitivity in patients with essential hypertension.

synapsesocial.com/papers/6a632fab4f5ef41b946aaa67 https://doi.org/10.1161/01.hyp.0000078490.59735.6e

Topics

Hypertension management

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Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider