Key result
Chronic prazosin therapy in men with essential hypertension was accompanied by a diminution in total renovascular resistance and plasma renin activity.
Why the study?
Does chronic prazosin therapy alter renal hemodynamics in men with essential hypertension?
Observational (n=10)
Does chronic prazosin therapy alter renal hemodynamics in men with essential hypertension?
Answers are grounded in this paper and cite their sources.
Shows reduced renal resistance in men with hypertension, indicating potential therapy benefits.
Renal hemodynamic effects of chronic prazosin therapy were studied in 10 men and with essential hypertension. Successful antihypertensive therapy was accompanied by diminution in total renovascular resistance, probably at the level of the afferent arteriole. The resistance change was unexplained by alterations in intravascular volume, the vasodilatory renal kallikrein-kinin system, or sympathetic nervous system activity, but was associated with a diminution in plasma renin activity. Potential mechanisms for the resistance decrement are discussed, including renal perfusion autoregulation, diminished activity of the vasoconstrictive renin-angiotensin system, and direct intrarenal afferent arteriolar alpha adrenergic blockade.
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Preston et al. (1979) conducted an observational in essential hypertension (n=10). Chronic prazosin therapy was evaluated on Total renovascular resistance. Chronic prazosin therapy in men with essential hypertension was accompanied by a diminution in total renovascular resistance and plasma renin activity.
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