What question did this study set out to answer?

Assess the antihypertensive efficacy, hemodynamic mechanisms, and posture-dependent blood pressure responses of prazosin in preclinical animal models and hypertensive patients.

January 1, 1974Clinical Science

Prazosin in the Treatment of Hypertension

View Full Paper

Ask AI

Bookmark

Authors

ISI. Sanford SmithHahnemann University Hospital AWA WederUniversity of Applied Sciences Wedel KKK. E. KimHahnemann University Hospital

Discussion

Member takes

Implication

Preclinical and clinical evaluation demonstrates blood pressure reduction via decreased peripheral resistance in hypertensive models and patients, indicating sustained therapeutic efficacy.

Key Points

Assess the antihypertensive efficacy, hemodynamic mechanisms, and posture-dependent blood pressure responses of prazosin in preclinical animal models and hypertensive patients.
Measured changes in blood pressure and heart rate following prazosin administration in normotensive, renal hypertensive, and spontaneously hypertensive rats.
Evaluated hemodynamics (total peripheral resistance and cardiac output) and long-term blood pressure responses in supine and standing hypertensive patients treated with prazosin alone or with a diuretic.
Prazosin lowered blood pressure across all rat models, showing the greatest reduction alongside a decreased heart rate in spontaneously hypertensive rats.
In hypertensive patients, prazosin decreased blood pressure primarily through a reduction in total peripheral resistance with minimal impact on cardiac output.
Long-term therapeutic efficacy was maintained both as monotherapy and combined with a diuretic, showing equivalent blood pressure reduction in supine and standing postures.

Cite This Study

Smith et al. (1974) studied this question.

synapsesocial.com/papers/6aa01d86963e757bfd7301a0 https://doi.org/10.1042/cs048181s

View Full Paper

Ask AI

Bookmark

Implication

Preclinical and clinical evaluation demonstrates blood pressure reduction via decreased peripheral resistance in hypertensive models and patients, indicating sustained therapeutic efficacy.

Prazosin in the Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Prazosin in the Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider