Key result
Prazosin achieved a satisfactory response (diastolic blood pressure ≤100 mm Hg) in 76% of patients with severe hypertension, reducing blood pressure by an average of 31/20 mm Hg.
Why the study?
Does prazosin reduce blood pressure in patients with severe hypertension?
Population
50 hypertensive patients, including 28 with left ventricular hypertrophy and 28 with renal impairment. In 44…
Design
Case_series
Follow-up
mean 6-6 months
Authors
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May support prazosin in severe hypertension; hypothesis-generating from case report and needs prospective validation.
Observational (n=50)
Does prazosin reduce blood pressure in patients with severe hypertension?
Prazosin is an effective antihypertensive agent that significantly reduces blood pressure in patients with severe hypertension, including those unresponsive to other therapies.
Hayes et al. (1962) conducted an observational in severe hypertension (n=50). Prazosin was evaluated on satisfactory response (diastolic blood pressure reduced to 100 mm Hg or less). Prazosin achieved a satisfactory response (diastolic blood pressure ≤100 mm Hg) in 76% of patients with severe hypertension, reducing blood pressure by an average of 31/20 mm Hg.
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