Prazosin in Severe Hypertension: Effect on Blood Pressure, Plasma Renin Activity and in Hypertensive Emergencies

50 patients with severe hypertension who had an inadequate response to or side effects from other agents. The cohort included 28 patients with left ventricular hypertrophy, 16 with exudative retinopathy, 8 with prior vascular episodes, and 24 with renal hypertension.

Prazosin, mean daily dose 12 mg for a mean duration of 6.6 months, commonly used in combination with beta-blocking agents and diuretics. Large single oral doses (usually 5 mg) were also used for urgent situations.

Reduction in blood pressuresurrogate