Key result
The mean duration of short gaps in ion-channel activations by junctional nicotinic receptors in frog muscle fibres depended on the agonist used (ACh 20 µs, SubCh 43 µs, DecCh 71 µs, CCh 13 µs).
Population
Adult frog muscle fibres (junctional nicotinic receptors)
Design
Preclinical
Authors
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In vitro frog muscle nicotinic receptor kinetics leave open relevance to human cardiac channels; hypothesis-generating for ion channel research.
The fine structure of ion-channel activations by nicotinic receptors in frog muscle reveals agonist-dependent short and intermediate gaps within bursts.
Colquhoun et al. (1985) studied this question. Acetylcholine and its analogues was evaluated on Ion-channel activations (bursts and gaps). The mean duration of short gaps in ion-channel activations by junctional nicotinic receptors in frog muscle fibres depended on the agonist used (ACh 20 µs, SubCh 43 µs, DecCh 71 µs, CCh 13 µs).
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