December 19, 2017The Thoracic and Cardiovascular Surgeon
New Targets for the Prevention of Chronic Rejection after Thoracic Organ Transplantation
Key result
A systematic review of experimental models identified new immunomodulatory targets for preventing cardiac allograft vasculopathy and chronic lung allograft dysfunction after thoracic transplantation.
Population
Experimental models in transplant immunology addressing chronic rejection after heart and lung transplantation
Design
Systematic_review
Authors
Discussion
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Member takes
Implication
Novel targets for CAV and CLAD merit clinical translation; extends mechanistic framework for chronic rejection after thoracic transplantation.
Study Design
Type
Systematic Review
Structured PICO
P
Population
Experimental models in transplant immunology addressing chronic rejection after heart and lung transplantation
I
Intervention
New targets and strategies for the prevention of chronic rejection (cardiac allograft vasculopathy and chronic lung allograft dysfunction)
O
Outcome
Prevention of chronic rejection (cardiac allograft vasculopathy and chronic lung allograft dysfunction)
Recent experimental research has identified new potential targets for preventing chronic rejection after thoracic organ transplantation, though clinical translation remains necessary.
Cite This Study
Gocht et al. (2017) conducted a systematic review in Chronic rejection after thoracic organ transplantation (cardiac allograft vasculopathy and chronic lung allograft dysfunction). New immunomodulatory targets was evaluated. A systematic review of experimental models identified new immunomodulatory targets for preventing cardiac allograft vasculopathy and chronic lung allograft dysfunction after thoracic transplantation.