A novel human parechovirus, proposed as the prototype of HPeV-6, was isolated from a 1-year-old girl with Reye syndrome and was genetically and antigenically distinct from known HPeV types 1-5.
Observational (n=41)
No
The study identifies and characterizes a novel human parechovirus, HPeV-6, expanding the known diversity of this viral family associated with various clinical symptoms.
Using Vero cells, we isolated a virus (NII561-2000) from a cerebrospinal fluid specimen of a 1-year-old girl with Reye syndrome. The determined amino acid sequence of the virus indicated that the isolate was a human parechovirus (HPeV), a member of Picornaviridae. Neutralization test showed that the NII561-2000 virus had distinct antigenicity to HPeV-1, HPeV-2, and HPeV-3, and that the sequence was distinct from these types as well as from HPeV-4 and HPeV-5. Thus, we propose the virus (NII561-2000) as the prototype of HPeV-6. We isolated 10 NII561-2000-related viruses, 14 HPeV-1, 16 HPeV-3, and 1 HPeV-4 of 41 HPeVs from various clinical samples collected in Niigata, Japan. Clinical symptoms of the persons infected with the NII561-2000-related viruses were infectious gastroenteritis, rash, upper respiratory tract infection, and paralysis, in addition to Reye syndrome in the 1-year-old girl.
Watanabe et al. (Fri,) conducted a observational in Human parechovirus infection (n=41). Human parechovirus infection was evaluated on Viral isolation and genetic characterization. A novel human parechovirus, proposed as the prototype of HPeV-6, was isolated from a 1-year-old girl with Reye syndrome and was genetically and antigenically distinct from known HPeV types 1-5.
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