Key result
Cardiometabolic dysregulation was directly associated with cognitive decline and indirectly associated through increased depressive symptoms, which in turn predicted greater cognitive decline.
Why the study?
Does cardiometabolic dysregulation accelerate cognitive decline, and is this association mediated by depressive symptoms in community-dwelling adults?
Cohort (n=7,409)
Does cardiometabolic dysregulation accelerate cognitive decline, and is this association mediated by depressive symptoms in community-dwelling adults?
p-value: p=<0.001
Cardiometabolic dysregulation is associated with accelerated cognitive decline, and this relationship appears to be partially mediated by the development of depressive symptoms.
Depressive symptoms may mediate cardiometabolic-cognitive links; hypothesis-generating and requires prospective trials before clinical adoption.
BACKGROUND: Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. Aims To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies. METHOD: Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469). RESULTS: Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively). CONCLUSIONS: Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline. Declaration of interest None.
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Schmitz et al. (2018) conducted a cohort in Cardiometabolic dysregulation and cognitive decline (n=7,409). Cardiometabolic dysregulation vs. No cardiometabolic risk factors was evaluated on Cognitive decline (latent change score) (p=<0.001). Cardiometabolic dysregulation was directly associated with cognitive decline and indirectly associated through increased depressive symptoms, which in turn predicted greater cognitive decline.
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