What question did this study set out to answer?

This research aims to investigate the distribution of the CYP2C19 poor metabolizer phenotype and genotypes among Caucasian populations of European descent.

October 1, 1999Pharmacogenetics

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4???-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

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Authors

HXHong‐Guang XieRice Research Institute CSC. Michael SteinUniversity of Wisconsin–Madison RKRichard B. KimWestern University

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Implication

Pooled analysis shows CYP2C19 poor metabolizer frequency in Caucasians, indicating genetic variation.

Key Points

This research aims to investigate the distribution of the CYP2C19 poor metabolizer phenotype and genotypes among Caucasian populations of European descent.
Conducted a pooled analysis of 22 homogeneous studies assessing CYP2C19 phenotyping and genotyping.
Analyzed data from 3990 individuals for phenotyping and 1356 for genotyping.
Examined the frequencies of Mendelian genotypes among the study population.
The phenotypic frequency of poor metabolizers was found to be 2.8% (110 of 3990; 95% CI 2.3-3.3).
The genotypic frequency of poor metabolizers was 2.1% (28 of 1356; 95% CI 1.3-2.8), consistent with phenotyping results.
Approximately 10% of the identified poor metabolizer alleles were unknown among tested individuals.

Cite This Study

Xie et al. (1999) studied this question.

synapsesocial.com/papers/6a63594a84b804377828acb0 https://doi.org/10.1097/00008571-199910000-00001

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Allelic, genotypic and phenotypic distributions of S-mephenytoin 4???-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

Discussion

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Implication

Key Points

Cite This Study

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4???-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

Discussion

Member takes

Implication

Key Points

Cite This Study

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