Key result
Lipolysis-induced modification of VLDL-E, but not lipid transfer, led to apolipoprotein B epitope expression and subsequent binding of apoE and heparin, indicating a two-step reaction.
Population
Human plasma very low density lipoprotein (VLDL) particles initially containing no apolipoprotein E (VLDL-E)
Comparison
Modification of lipid content through the action… vs Modification of lipid content by lipid transfer…
Design
Preclinical
Authors
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Lipolysis-induced apoB change enables apoE binding in animal VLDL; leaves open relevance to human lipoprotein clearance.
The binding of apolipoprotein E to VLDL requires a structural change in apolipoprotein B induced by lipolysis, rather than just a change in lipid composition.
Ishikawa et al. (1988) studied this question. Modification of VLDL lipid content via lipoprotein lipase vs. Modification via lipid transfer without lipolysis was evaluated on Binding of apoE and heparin to VLDL. Lipolysis-induced modification of VLDL-E, but not lipid transfer, led to apolipoprotein B epitope expression and subsequent binding of apoE and heparin, indicating a two-step reaction.
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