Key result
Acid reflux disease may trigger paroxysmal atrial fibrillation, while proton pump inhibitors may ameliorate AF symptoms and facilitate conversion to normal sinus rhythm in a subset of patients.
Why the study?
Do proton pump inhibitors (PPIs) ameliorate symptoms and facilitate conversion to normal sinus rhythm in patients with atrial fibrillation and acid reflux disease?
Population
Patients with atrial fibrillation and acid reflux disease
Design
Review
Authors
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Hypothesis-generating for vagal or inflammatory link between esophagitis and paroxysmal AF; larger studies needed before clinical consideration.
Do proton pump inhibitors (PPIs) ameliorate symptoms and facilitate conversion to normal sinus rhythm in patients with atrial fibrillation and acid reflux disease?
Acid reflux disease may trigger atrial fibrillation via inflammation and vagal stimulation, and PPI therapy could potentially ameliorate AF symptoms, highlighting a need for prospective studies.
Velagapudi et al. (2012) conducted a review in Atrial fibrillation and acid reflux disease. Proton pump inhibitors (PPIs) was evaluated. Acid reflux disease may trigger paroxysmal atrial fibrillation, while proton pump inhibitors may ameliorate AF symptoms and facilitate conversion to normal sinus rhythm in a subset of patients.
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