Key result
Proton pump inhibitor therapy led to a decrease or disappearance of at least one PAF-related symptom in 78% (14 of 18) of patients with lone paroxysmal atrial fibrillation and reflux esophagitis.
Why the study?
Does proton pump inhibitor (PPI) therapy reduce PAF-related symptoms in patients with lone paroxysmal atrial fibrillation and reflux esophagitis?
Observational (n=18)
Does proton pump inhibitor (PPI) therapy reduce PAF-related symptoms in patients with lone paroxysmal atrial fibrillation and reflux esophagitis?
PPI therapy may reduce PAF-related symptoms in patients with lone paroxysmal atrial fibrillation and concurrent reflux esophagitis, suggesting GERD as a potential pathogenetic mechanism.
Answers are grounded in this paper and cite their sources.
PPI may reduce PAF symptoms in patients with reflux esophagitis; hypothesis-generating and requires randomized confirmation before practice change.
BACKGROUND: We sought to assess whether proton pump inhibitor (PPI) therapy of gastroesophageal reflux disease (GERD) in patients with lone paroxysmal atrial fibrillation (PAF) leads to a reduction of PAF-related symptoms. METHODS: The records of patients with reflux esophagitis were screened for the diagnosis of lone PAF. All patients with reflux esophagitis and lone PAF were invited for a follow-up visit, at which PAF- and GERD-related symptoms, medication, and electrocardiogram were recorded. RESULTS: Among 89 patients, 18 (6 women, aged 39-69 years) had lone PAF. Decrease or disappearance of at least one PAF-related symptom occurred in 14 of 18 patients (78%) after PPI therapy. In two of the remaining four patients, GERD-related symptoms persisted. Antiarrhythmic drugs were discontinued in five patients, and none had to be increased in dosage or newly prescribed. The electrocardiogram showed sinus rhythm in all patients. CONCLUSION: In lone PAF, GERD should be investigated as a potential pathogenetic mechanism. PPI therapy reduces not only GERD-related but also PAF-related symptoms.
No takes yet. Share an insight, caveat, or question.
Weigl et al. (2003) conducted an observational in Lone paroxysmal atrial fibrillation and reflux esophagitis (n=18). Proton pump inhibitor (PPI) therapy was evaluated on Decrease or disappearance of at least one PAF-related symptom. Proton pump inhibitor therapy led to a decrease or disappearance of at least one PAF-related symptom in 78% (14 of 18) of patients with lone paroxysmal atrial fibrillation and reflux esophagitis.
Synapse has enriched 10 related papers. Consider them for comparative context: