Key result
In men with combined hyperlipidemia, TNF-α, IL-6, and apo B explained 87% of FMD variability, while total tissue factor pathway inhibitor and apo B explained 82% of carotid IMT variation.
Cross-Sectional (n=72)
In asymptomatic overweight men with combined hyperlipidemia, apolipoprotein B is associated with both functional and morphological arterial changes, whereas proinflammatory cytokines associate with functional changes and coagulation parameters with morphological changes.
Apo B links endothelial dysfunction and carotid thickening in combined hyperlipidemia; hypothesis-generating, longitudinal studies needed before clinical translation.
In Brief Background Early functional and morphological changes in the course of the atherosclerotic process are manifested as endothelial dysfunction and increased intima–media thickness (IMT) of the arterial wall. These are both associated with various atherosclerotic risk factors. We investigated whether the same factors are associated with functional and morphological changes of the arterial wall in men with combined hyperlipidemia. Methods Flow-mediated dilatation (FMD) of the brachial artery and carotid IMT were measured in 72 male patients aged 46±5 years with combined hyperlipidemia. Serum lipoproteins, fibrinolytic and coagulation parameters, blood glucose, proinflammatory cytokines and C-reactive protein were also measured. Results Tumor necrosis factor-α, interleukin 6 and apolipoprotein (apo) B were found to be independent predictors of FMD, explaining 87% of FMD variability in multivariate analysis. On the other hand, total tissue factor pathway inhibitor and apo B were independent predictors of increased carotid IMT, explaining 82% of the variation in carotid IMT. Conclusions Apo B, which is a marker for the presence of the atherogenic lipoproteins, is associated with both functional and morphological changes of the artery wall. In addition, in asymptomatic overweight middle-aged men with combined hyperlipidemia, functional changes are associated with proinflammatory cytokines, while morphological changes are associated with coagulation parameters. Atherosclerotic process begins with functional changes of arterial wall and it is continued with morpholigical ones. We examined which factor are involved in these changen in asymtomatic middle.aged males with combined hyper-lipidemia. Apo B, was found to be associated with both functional and morphological changes of the artery wall. Beside that, functional changes of artery wall are also associated with proinflammatory cytokines, while the morphological ones are associated with coagulation parameters.
No takes yet. Share an insight, caveat, or question.
tjen et al. (2005) conducted a cross-sectional in combined hyperlipidemia (n=72). Apolipoprotein B, proinflammatory cytokines, and coagulation parameters was evaluated on Flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (IMT). In men with combined hyperlipidemia, TNF-α, IL-6, and apo B explained 87% of FMD variability, while total tissue factor pathway inhibitor and apo B explained 82% of carotid IMT variation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: