Key result
Ageing in rats is associated with a deterioration in both basal and stimulated release of nitric oxide by the coronary endothelium, while the response to glyceryl trinitrate remains unaltered.
Why the study?
Does ageing reduce basal and stimulated release of nitric oxide by the coronary endothelium in rats?
Population
Four groups of rats of different ages (1, 5, 15 and 26 months)
Comparison
Ageing (older age groups) vs Younger age groups
Design
Preclinical
Authors
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Suggests age-related coronary endothelial dysfunction in rats; leaves open translation to human cardiovascular ageing.
Does ageing reduce basal and stimulated release of nitric oxide by the coronary endothelium in rats?
Ageing is associated with a deterioration in both basal and stimulated release of nitric oxide by the coronary endothelium in rats.
Amrani et al. (1996) studied Ageing. Ageing vs. Younger age was evaluated on Basal and stimulated release of nitric oxide by the coronary endothelium. Ageing in rats is associated with a deterioration in both basal and stimulated release of nitric oxide by the coronary endothelium, while the response to glyceryl trinitrate remains unaltered.
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