Key result
Multimodality cardiac imaging to guide left ventricular pacing increased the positive response to cardiac resynchronization therapy compared to standard practice (78% vs 56%, P=0.019).
Why the study?
Does multimodality cardiac imaging-guided CRT implantation improve the echocardiographic response rate in heart failure patients compared to standard clinical practice?
Population
100 heart failure patients who are candidates for cardiac resynchronization therapy (CRT).
Comparison
CRT implantation guided by a 'CRT team' using… vs CRT device implanted according to standard…
Design
Cohort
Follow-up
6 months
Authors
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Targeting LV lead via CMR-strain may raise CRT response rates; leaves open randomized confirmation of targeting benefit.
Cohort (n=100)
Does multimodality cardiac imaging-guided CRT implantation improve the echocardiographic response rate in heart failure patients compared to standard clinical practice?
Absolute Event Rate: 78% vs 56%
p-value: p=0.019
Guiding left ventricular lead placement during CRT implantation using multimodality imaging (CMR and strain echocardiography) significantly increases the rate of echocardiographic response compared to standard practice.
Bertini et al. (2016) conducted a cohort in Heart failure (n=100). Multimodality cardiac imaging (CMR and longitudinal myocardial strain) guided CRT vs. Standard clinical practice was evaluated on Positive response to CRT (reduction of ≥15% of the LV end-systolic volume at 6-month follow-up) (p=0.019). Multimodality cardiac imaging to guide left ventricular pacing increased the positive response to cardiac resynchronization therapy compared to standard practice (78% vs 56%, P=0.019).
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