Key result
Low sarcopenia index is linked to ~2-fold higher risk of coronary slow flow.
Why the study?
To examine the association between the sarcopenia index and the risk of intraprocedural events and post-discharge death in patients undergoing PCI.
Does a low sarcopenia index predict intraprocedural events and post-discharge mortality in patients undergoing percutaneous coronary intervention?
Cohort (n=497)
No
Does a low sarcopenia index predict intraprocedural events and post-discharge mortality in patients undergoing percutaneous coronary intervention?
Odds Ratio: 2.01 (95% CI 1.04–3.89)
Absolute Event Rate: 16.94% vs 9.65%
p-value: p=0.038
A low sarcopenia index, calculated simply from serum creatinine and cystatin C, may serve as a useful surrogate marker to predict the risk of intraprocedural coronary slow flow in patients undergoing PCI.
OBJECTIVES: To examine the association between the sarcopenia index (SI) and the risk of intraprocedural events and post-discharge death during percutaneous coronary intervention (PCI). DESIGN: A retrospective cohort study. SETTING: The study was conducted at a teaching hospital in Western China. PARTICIPANTS: . Patients who died during hospitalisation, as well as those with unknown death dates, those lost to follow-up and those with missing information for the SI calculation, were excluded. PRIMARY AND SECONDARY OUTCOME MEASURES: The SI was calculated as serum creatinine/cystatin C (Cr/CysC) × 100. The high-SI group was defined as the highest quartile, while the remaining participants were included in the low-SI group. Intraprocedural events included intraprocedural coronary slow flow (CSF)/coronary artery no-reflow (CNR) and malignant ventricular arrhythmia (MVA). In the event of death, the date of death was recorded. RESULTS: The study included 497 patients who underwent PCI in our hospital, of whom 369 (74.25%) were males. A total of 57 (11.47%) patients developed CSF, 100 (20.12%) developed CNR and 4 (0.8%) developed MVA. Forty-four (8.85%) patients died post-discharge. The proportion of patients in the low-SI group who developed CSF was higher than those who did not (16.94% vs 9.65%, p=0.027). In addition, the average SI was lower in patients who developed CSF than in those who did not (81.99 vs 87.11, p=0.043). After adjusting for possible confounding factors, logistic regression analysis showed that the risk of CSF in the low-SI group was higher than that in the high-SI group (OR = 2.01, 95% CI: 1.04 to 3.89). In addition, it was found that the lower the SI, the higher the risk of CSF (OR = 0.983, 95% CI: 0.967 to 0.999). CONCLUSIONS: Patients with lower SI had a greater risk of developing CSF, and the lower the SI, the higher the risk of CSF. However, these data suggest that SI is not associated with CNR and the risk of post-discharge death in patients after PCI.
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Lu et al. (2024) conducted a cohort in Coronary artery disease undergoing PCI (n=497). Low sarcopenia index (SI) vs. High sarcopenia index (SI) was evaluated on Intraprocedural coronary slow flow (CSF) (OR 2.01, 95% CI 1.04 to 3.89, p=0.038). A low sarcopenia index was independently associated with a significantly higher risk of intraprocedural coronary slow flow compared to a high sarcopenia index (adjusted OR 2.01, 95% CI 1.04 to 3.89).
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