Key result
Cell-cell and cell-extracellular matrix interactions play an integral role in cardiogenesis, and their disruption can result in numerous congenital heart defects.
Understanding cell-cell and cell-ECM interactions during cardiovascular development is crucial for developing novel therapeutic strategies for congenital heart disorders.
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ECM interactions may inform congenital heart defect models; leaves open targeted developmental cardiology research.
Cardiac development is reliant upon the spatial and temporal regulation of both genetic and chemical signals. Central to the communication of these signals are direct interactions between cells and their surrounding environment. The extracellular matrix (ECM) plays an integral role in cell communication and tissue growth throughout development by providing both structural support and chemical signaling factors. The present review discusses elements of cell-cell and cell-ECM interactions involved in cardiogenesis, and how disruption of these interactions can result in numerous heart defects. Examining the relationships between cells and their immediate environment has implications for novel and existing therapeutic strategies to combating congenital disorders.
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Bowers et al. (2010) conducted a review in Cardiovascular development and congenital disorders. Cell-cell and cell-ECM interactions was evaluated. Cell-cell and cell-extracellular matrix interactions play an integral role in cardiogenesis, and their disruption can result in numerous congenital heart defects.
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