Key result
Captopril normalized blood pressure in 75% of elderly patients (lowering mean BP to 161/78 mm Hg), producing similar reductions to triamterene/hydrochlorothiazide but without biochemical changes.
Why the study?
Does captopril improve blood pressure and tolerability compared to triamterene and hydrochlorothiazide in elderly patients with mild to moderate hypertension?
Population
n=40 elderly patients with mild to moderate hypertension.
Comparison
Captopril (single daily dose) vs Triamterene and hydrochlorothiazide
Design
RCT, randomized cross-over, single-blind, placebo-controlled
Authors
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Both agents lower BP in elderly hypertensives; hypothesis-generating and leaves open optimal first-line choice.
RCT (n=40)
Single-blind
Cross-over
Does captopril improve blood pressure and tolerability compared to triamterene and hydrochlorothiazide in elderly patients with mild to moderate hypertension?
Captopril is an effective and better-tolerated monotherapy for mild to moderate hypertension in the elderly compared to triamterene/hydrochlorothiazide, avoiding adverse renal biochemical changes.
Jean Woo (1987) conducted an RCT in Mild to moderate hypertension (n=40). Captopril vs. Triamterene and hydrochlorothiazide was evaluated on Blood pressure. Captopril normalized blood pressure in 75% of elderly patients (lowering mean BP to 161/78 mm Hg), producing similar reductions to triamterene/hydrochlorothiazide but without biochemical changes.
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