Population
Miniature pigs (n=36)
Comparison
4% cholesterol diet for 6, 14, or 24 weeks to… vs Control pigs (implied normal diet)
Design
Preclinical
Follow-up
up to 24 weeks
Key result
A 4% cholesterol diet in miniature pigs for 24 weeks resulted in compensatory vessel enlargement, increasing mean luminal area from 1.42 mm2 in controls to 4.38 mm2 (P=0.007).
Authors
Loading...
Does not inform clinical practice; hypothesis-generating for oxidized LDL in experimental plaque progression.
Absolute Event Rate: 4.38% vs 1.42%
p-value: p=0.007
In a miniature pig model, accumulation of oxidized LDL in coronary plaques correlates strongly with plaque growth and compensatory vessel enlargement, independent of plasma LDL levels.
Holvoet et al. (1998) studied LDL-hypercholesterolemia (n=36). 4% cholesterol diet vs. Control diet was evaluated on Mean luminal area at 24 weeks (p=0.007). A 4% cholesterol diet in miniature pigs for 24 weeks resulted in compensatory vessel enlargement, increasing mean luminal area from 1.42 mm2 in controls to 4.38 mm2 (P=0.007).