Why the study?
Does balloon catheter injury to diet-induced coronary atherosclerotic plaques promote thrombus formation in normal and von Willebrand disease swine?
Population
14 paired normal swine and bleeder swine with homozygous von Willebrand disease on a 1% cholesterol diet for…
Comparison
Balloon catheter injury to coronary… vs Normal swine compared to bleeder swine; intimal…
Design
Preclinical
Follow-up
1 to 16 weeks
Key result
Balloon catheter injury to intimal foam cell lesions in cholesterol-fed swine did not promote platelet-fibrin thrombus formation, whereas injury extending to the media formed mixed thrombi.
Authors
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Intimal injury may not trigger thrombosis in atherosclerotic swine; leaves open medial depth and vWF dependence for human plaque rupture models.
Does balloon catheter injury to diet-induced coronary atherosclerotic plaques promote thrombus formation in normal and von Willebrand disease swine?
In a swine model of atherosclerosis, balloon injury to the intima does not provoke platelet-fibrin thrombus formation, but deeper injury extending to the media does, with von Willebrand disease reducing platelet spreading.
Reddick et al. (1990) studied Coronary atherosclerosis (n=28). Balloon catheter injury vs. Normal vs bleeder swine phenotypes was evaluated on Platelet deposition and thrombus formation. Balloon catheter injury to intimal foam cell lesions in cholesterol-fed swine did not promote platelet-fibrin thrombus formation, whereas injury extending to the media formed mixed thrombi.