Key result
Homozygous von Willebrand's disease in swine significantly reduced the extent of aortic fibrous plaques compared to normal swine (2.37% vs 3.88%, P<0.05), but did not affect the development of coronary atherosclerosis.
Why the study?
Does the absence of von Willebrand factor prevent the development of coronary and aortic atherosclerosis following balloon injury and atherogenic diet in a swine model?
Population
Normal pigs and pigs homozygous and heterozygous for von Willebrand's disease
Comparison
Normal pigs vs carrier pigs vs bleeder pigs after balloon injury and atherogenic diet
Authors
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vWD swine data do not inform human care; leaves open vWF's site-specific role in atherosclerosis.
Does the absence of von Willebrand factor prevent the development of coronary and aortic atherosclerosis following balloon injury and atherogenic diet in a swine model?
Absolute Event Rate: 2.37% vs 3.88%
p-value: p=<0.05
In a swine model, the absence of von Willebrand factor reduces the extent of aortic atherosclerosis but does not protect against the development of coronary atherosclerosis following balloon injury.
Sultzer et al. (2020) studied Atherosclerosis (n=21). Homozygous von Willebrand's disease (bleeder phenotype) vs. Normal (wild-type) swine was evaluated on Extent of distal fibrous plaque lesions of the aorta (% total area) (p=<0.05). Homozygous von Willebrand's disease in swine significantly reduced the extent of aortic fibrous plaques compared to normal swine (2.37% vs 3.88%, P<0.05), but did not affect the development of coronary atherosclerosis.
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