Why the study?
Does the presence of von Willebrand factor affect platelet adhesion and activation following coronary artery injury in a swine model?
Population
Normal swine and swine with von Willebrand disease (vWD)
Comparison
Coronary endothelial denudation vs Normal swine compared to swine with von…
Design
Preclinical
Follow-up
30 minutes
Authors
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Swine model links vWF to platelet activation but not adhesion post-injury; hypothesis-generating and leaves open human coronary relevance.
Does the presence of von Willebrand factor affect platelet adhesion and activation following coronary artery injury in a swine model?
Von Willebrand factor is required for platelet spreading and activation, but not initial adhesion, following coronary artery injury in a swine model.
Reddick et al. (1982) studied this question.
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