Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1986Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

There was a significant positive relationship between serum cholesterol concentration and the extent of intimal lesions (r = 0.62, p = 0.006), with no differences observed between phenotypes or between ballooned and nonballooned vessels (p > 0.05).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does acute intimal injury or von Willebrand factor influence the development of coronary atherosclerosis in swine with severe hypercholesterolemia?

Population

18 swine (9 normal, 9 with von Willebrand's disease) maintained on a 2% cholesterol diet

Comparison

Acute intimal injury via endothelial denudation… vs Nonballooned control vessels and comparison…

Design

Preclinical

Follow-up

4 months

Authors

TGThomas R. GriggsRBR W BaumanRRRobert L. Reddick

Discussion

Loading...

Member takes

Overview

Severe hypercholesterolemia drives intimal lesions independently in swine; leaves open vWF or injury roles in human atherosclerosis.

Structured PICO

Does acute intimal injury or von Willebrand factor influence the development of coronary atherosclerosis in swine with severe hypercholesterolemia?

P
Population
18 swine (9 normal, 9 with von Willebrand's disease) maintained on a 2% cholesterol diet
I
Intervention
Acute intimal injury via endothelial denudation by balloon catheterization of the left anterior descending coronary artery
C
Comparator
Nonballooned control vessels (circumflex and right coronary arteries) and comparison between normal vs. von Willebrand's disease phenotypes
O
Outcome
Extent of atherosclerotic involvement evaluated by percent intimal area, percent luminal narrowing, ratio of intimal to medial area, and luminal formsurrogate

In a swine model, severe hypercholesterolemia promotes coronary atherosclerosis independently of acute intimal injury or von Willebrand factor.

Cite This Study

Griggs et al. (1986) studied this question.

synapsesocial.com/papers/6a7118fea2d7cf2e39c2c09ehttps://doi.org/10.1161/01.atv.6.2.155
View Full Paper
Ask AI
Bookmark
Share