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July 1, 1986Circulation ResearchOpen Access

von Willebrand's disease prevents occlusive thrombosis in stenosed and injured porcine coronary arteries.

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Why the study?

Does von Willebrand's disease prevent occlusive thrombosis following coronary stenosis and intimal injury in a porcine model?

Population

19 pigs subjected to coronary stenosis with a Goldblatt clamp and intimal injury with spring-loaded forceps.

Comparison

von Willebrand's disease vs Phenotypically normal pigs

Design

Preclinical

Authors

TNTimothy C. NicholsUniversity of North Carolina at Chapel HillDBDwight A. BellingerUniversity of North Carolina at Chapel HillTJTimothy A. JohnsonPurdue University West Lafayette

Discussion

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Overview

Findings in this porcine model should not yet influence clinical practice; leaves open von Willebrand factor targeting for human coronary thrombosis.

Structured PICO

Does von Willebrand's disease prevent occlusive thrombosis following coronary stenosis and intimal injury in a porcine model?

P
Population
19 pigs (9 phenotypically normal, 10 with von Willebrand's disease [heterozygous and homozygous]) subjected to coronary stenosis with a Goldblatt clamp and intimal injury with spring-loaded forceps.
I
Intervention
von Willebrand's disease (genetic absence or reduction of von Willebrand factor, including 4 pigs given purified von Willebrand factor at a dose failing to correct bleeding time)
C
Comparator
Phenotypically normal pigs
O
Outcome
Cyclic flow reductions or permanent cessation of coronary blood flow velocitysurrogate

Native von Willebrand factor plays a critical role in mediating sudden occlusive arterial thrombosis following coronary stenosis and intimal injury in a porcine model.

Cite This Study

Nichols et al. (1986) studied this question.

synapsesocial.com/papers/6a968db5f34ac7d5e5822bc6https://doi.org/10.1161/01.res.59.1.15
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand's disease.2020 · 68 citations
  2. 2Effects of thromboxane synthetase inhibitors on cyclical reduction of coronary blood flow in dogs.1981 · 13 citations
  3. 3Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease1978 · 281 citations
  4. 4Hemostatic Effect of Transfused Willebrand Factor in Porcine von Willebrand’s Disease2009 · 17 citations