Aortic atherosclerosis in pigs with heterozygous von Willebrand disease. Comparison with homozygous von Willebrand and normal pigs.
Why the study?
Does heterozygous von Willebrand disease confer resistance to diet-induced atherosclerosis in pigs compared to normal pigs?
Population
19 pigs fed a high fat, high cholesterol diet from age 3 to 9 months
Comparison
Heterozygous von Willebrand disease and… vs Normal pigs
Design
Preclinical
Follow-up
6 months (from age 3 to 9 months)
Authors
Discussion
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Member takes
Implication
No atherosclerosis resistance with moderate vWF reduction in heterozygous pigs; leaves open human vWD relevance.
Structured PICO
Does heterozygous von Willebrand disease confer resistance to diet-induced atherosclerosis in pigs compared to normal pigs?
P
Population
19 pigs (9 normal, 5 homozygous vWd, 5 heterozygous vWd) fed a high fat, high cholesterol (2%) diet from age 3 to 9 months
I
Intervention
Heterozygous von Willebrand disease (moderate reduction of VIII R:AG and VIII:RWF) and homozygous von Willebrand disease (undetected VIII R:AG and VIII:RWF)
C
Comparator
Normal pigs (normal factor VIII antigen and ristocetin co-factor)
O
Outcome
Percentage of atherosclerotic involvement of the distal aortic surface and the entire aortasurrogate
Moderate reduction of von Willebrand factor in heterozygous vWd pigs does not confer resistance to diet-induced atherosclerosis, suggesting humans with vWd may not be protected.
Cite This Study
Badimón et al. (1985) studied this question.