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July 1, 1995Arteriosclerosis Thrombosis and Vascular Biology

The Biologic Behavior of Balloon Hyperinflation–Induced Arterial Lesions in Hypercholesterolemic Pigs Depends on the Presence of Foam Cells

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Why the study?

Does an atherogenic diet combined with balloon hyperinflation injury induce complex atherosclerosis-like lesions in minipigs compared to a standard diet?

Population

Minipigs (n=34)

Comparison

Atherogenic diet combined with deep injury to a… vs Standard diet combined with deep injury to a…

Design

Preclinical

Follow-up

1 month

Authors

DRDino RecchiaDADana R. AbendscheinJSJeffrey E. Saffitz

Discussion

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Overview

Supports minipig models of foam cell-driven thrombosis; leaves open human plaque vulnerability translation.

Structured PICO

Does an atherogenic diet combined with balloon hyperinflation injury induce complex atherosclerosis-like lesions in minipigs compared to a standard diet?

P
Population
Minipigs (n=34)
I
Intervention
Atherogenic diet combined with deep injury to a carotid artery by repetitive balloon hyperinflations
C
Comparator
Standard diet combined with deep injury to a carotid artery by repetitive balloon hyperinflations (n=4)
O
Outcome
Development and composition of complex atherosclerosis-like lesions (including foam cells, thrombus, hemorrhage, and calcification) at 1 monthsurrogate

In a minipig model, balloon hyperinflation combined with hypercholesterolemia rapidly induces complex atherosclerotic lesions whose composition and thrombotic behavior depend on the degree of hypercholesterolemia and foam cell accumulation.

Cite This Study

Recchia et al. (1995) studied this question.

synapsesocial.com/papers/6a7bcdbf073f483584df9334https://doi.org/10.1161/01.atv.15.7.924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary atherosclerosis in the pig. Induced plaque injury and platelet response.1990 · 19 citations
  2. 2Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery.1991 · 73 citations
  3. 3Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty2002 · 27 citations
  4. 4Development of coronary atherosclerosis in swine with severe hypercholesterolemia. Lack of influence of von Willebrand factor or acute intimal injury.1986 · 29 citations
  5. 5LDL Hypercholesterolemia Is Associated With Accumulation of Oxidized LDL, Atherosclerotic Plaque Growth, and Compensatory Vessel Enlargement in Coronary Arteries of Miniature Pigs1998 · 115 citations