Key result
HDL efflux capacity and HDL particle number were inversely associated with prevalent LRNC plaque in unadjusted models (OR 0.5; 95% CI 0.26-0.96), but not after multivariable adjustment.
Why the study?
Are HDL efflux capacity and HDL particle size associated with high-risk carotid atherosclerosis in asymptomatic older adults?
Cohort
Are HDL efflux capacity and HDL particle size associated with high-risk carotid atherosclerosis in asymptomatic older adults?
HDL efflux capacity and particle number are not independently associated with prevalent high-risk carotid plaque after multivariable adjustment in asymptomatic older adults.
= 0.018) HDL particle concentration in multivariable adjusted models. HDL efflux capacity and HDL particle number were inversely associated with prevalent LRNC plaque in unadjusted models (odds ratio: 0.5; 95% confidence interval: 0.26, 0.96), but not after multivariable adjustment. HDL particle size was not associated with prevalent LRNC. HDL particle size was significantly associated with HDL efflux capacity, suggesting that differences in HDL efflux capacity may be due to structural differences in HDL particles. Future research is needed to determine whether HDL efflux is a marker of ASCVD risk in older populations.
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Mutharasan et al. (2017) conducted a cohort in High-risk carotid atherosclerosis. HDL efflux capacity and HDL particle number was evaluated on Prevalent LRNC plaque (OR 0.5, 95% CI 0.26, 0.96). HDL efflux capacity and HDL particle number were inversely associated with prevalent LRNC plaque in unadjusted models (OR 0.5; 95% CI 0.26-0.96), but not after multivariable adjustment.
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