Key result
Tailoring antiplatelet therapy based on platelet function testing for clopidogrel response is recommended to reduce thromboembolic events in patients undergoing neurointervention procedures.
Why the study?
Variable individual pharmacodynamic responses to antiplatelet drugs make selecting adequate regimens and optimal doses challenging for preventing thromboembolic events during neurointervention procedures.
Does tailoring antiplatelet therapy based on platelet function testing prevent thromboembolic events in patients undergoing neurointervention?
Does tailoring antiplatelet therapy based on platelet function testing prevent thromboembolic events in patients undergoing neurointervention?
Tailoring antiplatelet therapy using platelet function testing may help optimize dosing and prevent thromboembolic events in patients undergoing neurointerventions.
Variable clopidogrel responses may raise thromboembolic risk in neurointerventions; leaves open optimal testing and regimens.
As more intracranial aneurysms and other cerebrovascular pathologies are treated with neurointervention procedure, thromboembolic events that frequently lead to serious neurological deficit or fatal outcomes are increasing. In order to prevent the thromboembolic events, antiplatelet therapy is used in most procedures including coil embolization, stenting, and flow diversion. However, because of variable individual pharmacodynamics responses to antiplatelet drugs, especially clopidogrel, it is difficult for clinicians to select the adequate antiplatelet regimen and its optimal dose. This article reviews the neurointervention literature related to antiplatelet therapy and suggests a strategy for tailoring antiplatelet therapy in individual patients undergoing neurointervention based on the results of platelet function testing.
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Yi et al. (2019) conducted a review in Cerebrovascular pathologies requiring neurointervention. Platelet function testing-guided antiplatelet therapy vs. Standard antiplatelet therapy was evaluated. Tailoring antiplatelet therapy based on platelet function testing for clopidogrel response is recommended to reduce thromboembolic events in patients undergoing neurointervention procedures.
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