Key result
Tricuspid valve morphology significantly increased the risk of atrioventricular valve failure (HR 8.24) compared to other morphologies over a median 17.6-year follow-up after the Fontan procedure.
Why the study?
Ventricular dysfunction and atrioventricular valve failure are associated with adverse outcomes in Fontan patients, but data on longitudinal changes and their relationship with morphology are lacking.
What are the longitudinal changes and morphologic risk factors for ventricular dysfunction and atrioventricular valve failure in patients following the Fontan procedure?
Cohort (n=174)
No
What are the longitudinal changes and morphologic risk factors for ventricular dysfunction and atrioventricular valve failure in patients following the Fontan procedure?
Long-term follow-up of Fontan patients reveals progressive decline in ventricular and AVV function, particularly in those with dominant right ventricle, tricuspid valve, or common AVV morphology.
Background: Ventricular dysfunction and atrioventricular valve (AVV) failure in Fontan patients are associated with adverse long-term outcomes; however, data on longitudinal changes and their relationship with morphology are lacking. This study aimed to describe longitudinal changes in ventricular function and AVV regurgitation and to determine the risk factors in Fontan patients who develop ventricular dysfunction and AVV failure. Methods: We retrospectively reviewed echocardiographic images from patients who underwent Fontan procedure from 1984 to 2015. Mixed-effects model fits a unique linear regression line using serial ejection fraction (EF) and AVV regurgitation. Multivariate logistic regression was performed to find morphologic risk factors for ventricular dysfunction and AVV failure. Results: Out of 174 patients who underwent 3,203 echocardiograms, a significant 6.2% decrease in EF was observed (P<0.001) over a median follow-up of 17.6 years (interquartile range, 15.3-19.2 years) post Fontan procedure. Higher prevalence of ventricular dysfunction (EF <50%) was noted in dominant right ventricle (RV) and two-ventricular (2V) morphologies compared to left ventricle (LV) (P<0.001). AVV failure was more common in RV and 2V morphologies as well (P<0.001). Notably, patients with tricuspid valve (TV) and common AVV exhibited the most pronounced AVV failure (P<0.001). In multivariate analysis, RV, TV and common AVV were correlated with AVV failure (hazard ratio 5.37, 8.24 and 5.43, respectively). Conclusions: Fontan patients with long-term follow-up showed a progressive decline in ventricular and AVV function. Dominant RV, TV and common AVV were prognostic factors for predicting AVV failure. Further studies are warranted to explore and validate these findings.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2025) conducted a cohort in Single ventricle physiology post-Fontan procedure (n=174). Tricuspid valve (TV) morphology vs. Mitral valve (MV) morphology was evaluated on Atrioventricular valve (AVV) failure (HR 8.24, 95% CI 3.53-22.74, p=<0.001). Tricuspid valve morphology significantly increased the risk of atrioventricular valve failure (HR 8.24) compared to other morphologies over a median 17.6-year follow-up after the Fontan procedure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: