Key result
Single ventricle patients with a common AV valve face ~62% valve failure at 28 years.
Why the study?
What is the long-term risk of atrioventricular valve failure in Fontan survivors with single ventricle physiology and common atrioventricular valve?
Population
136 Fontan survivors with single ventricle physiology and common atrioventricular valve
Design
Cohort
Follow-up
Median 10.2 years (interquartile range 5-15 years)
Authors
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Supports close long-term surveillance in Fontan patients with common AV valve; leaves open optimal intervention timing and strategies.
Cohort (n=136)
Yes
What is the long-term risk of atrioventricular valve failure in Fontan survivors with single ventricle physiology and common atrioventricular valve?
In Fontan survivors with a common atrioventricular valve, there is a continuous decline in valve function, with 62% experiencing valve failure by 28 years.
King et al. (2017) conducted a cohort in Single ventricle physiology and common atrioventricular valve (n=136). Observation was evaluated on Composite of atrioventricular valve failure (valve intervention or moderate or greater regurgitation) at 28 years (95% CI 49-74). Patients with single ventricle physiology and a common atrioventricular valve experienced a continuous decline in valve function, with a 62% cumulative incidence of valve failure at 28 years.
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