Key result
Fontan operation linked to progressively worsening global longitudinal and circumferential strain rates over 10 years.
Why the study?
There are little data on how echocardiographic parameters of ventricular function change over time in patients with single ventricle heart disease after Fontan operation.
Observational (n=40)
No
Effect estimate: 0.014 (1/s) per year
p-value: p=.02
Global longitudinal and circumferential strain rates worsen progressively over 10 years following the Fontan operation, potentially serving as early markers of cardiac dysfunction.
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Serial post-Fontan echo indices need prospective validation; leaves open their utility for risk stratification or intervention timing.
Campbell et al. (2020) conducted an observational in Single ventricle heart disease after Fontan operation (n=40). Time after Fontan operation vs. Patients without the composite outcome was evaluated on Longitudinal change in global longitudinal strain rate (0.014 (1/s) per year, p=.02). Over 10 years following Fontan operation, global longitudinal strain rate worsened by 0.014 (1/s) per year (P=0.02) and global circumferential strain rate worsened by 0.011 (1/s) per year (P=0.01).
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