Key result
Independent risk factors for cryopreserved homograft explantation included non-anatomical position (P=0.001), smaller graft size (P<0.0001), younger age (P<0.0001), and clamp time (P=0.01).
Why the study?
What are the factors influencing the survival and freedom from explantation of cryopreserved homografts implanted in the right ventricular outflow tract?
Population
272 patients undergoing pulmonary valve reconstruction with 301 homografts. Indications included tetralogy…
Design
Cohort
Follow-up
median 5.7 years (range 0-14)
Authors
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Patient age, homograft size, and position influence durability; leaves open optimal selection criteria for prospective validation.
Cohort (n=272)
What are the factors influencing the survival and freedom from explantation of cryopreserved homografts implanted in the right ventricular outflow tract?
p-value: p=<0.0001
The life span of cryopreserved homografts in the right ventricular outflow tract is primarily determined by graft size and non-anatomic position, with second homografts performing as well as the first.
Meyns et al. (2005) conducted a cohort in Pulmonary valve reconstruction (n=272). Risk factors (non-anatomical position, smaller graft size, younger age) was evaluated on Graft explantation (p=<0.0001). Independent risk factors for cryopreserved homograft explantation included non-anatomical position (P=0.001), smaller graft size (P<0.0001), younger age (P<0.0001), and clamp time (P=0.01).
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