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February 1, 1996Journal of Biological ChemistryOpen Access

Human Skeletal Muscle Nebulin Sequence Encodes a Blueprint for Thin Filament Architecture

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Key result

Analysis of the human fetal skeletal muscle nebulin sequence reveals its modular construction and super-repeat structure, which appear to encode thin filament architecture in resting muscle.

Population

Human fetal skeletal muscle nebulin sequence (~5500 residues)

Design

Preclinical

Authors

KWKuan WangSecond Military Medical UniversityMKMarie E. KnipferThe University of Texas at AustinQHQi Quan HuangNorthwestern University

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Implication

Defines nebulin super-repeat architecture; leaves open functional roles in sarcomeric myopathies.

Structured PICO

P
Population
Human fetal skeletal muscle nebulin sequence (~5500 residues)
E
Exposure
Analysis of deduced protein sequence and structural motifs
O
Outcome
Design principles, modular construction, super-repeat structure, and segmental organization of nebulin

The sequence and structural motifs of human skeletal muscle nebulin reveal its role as a giant actin-binding cofilament that encodes thin filament architecture.

Cite This Study

Wang et al. (1996) studied this question. Analysis of the human fetal skeletal muscle nebulin sequence reveals its modular construction and super-repeat structure, which appear to encode thin filament architecture in resting muscle.

synapsesocial.com/papers/6a63da32afcd897b869278fahttps://doi.org/10.1074/jbc.271.8.4304
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction1987 · 532 citations
  2. 2Three-dimensional reconstruction of caldesmon-containing smooth muscle thin filaments.1993 · 71 citations