Depression and mortality in a high-risk population
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Key result
Depression was associated with a 43% increased risk of mortality (HR 1.43) in older adults with moderate hypertension, independent of cardiovascular risk factors and cognitive decline.
Authors
Discussion
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Implication
Depression may independently raise mortality risk in older hypertensives; leaves open whether screening or treatment improves survival.
Study Design
Type
Cohort (n=2,584)
Multicenter
Yes
PICO
P
Population
2,584 older adults aged 65-75 years with moderate hypertension, free of serious cardiovascular disease or dementia, followed for 11 years.
E
Exposure / Comparator
Depression vs No depression
O
Primary Outcome
Mortality — HR 1.43 (1.03-1.98), p=0.040
Main Result
Hazard Ratio: 1.43 (95% CI 1.03–1.98)
p-value: p=0.040
Limitations
- Restricted to a relatively healthy group, limiting generalisability to younger or normotensive populations.
- Smoking was coded only as a binary variable, which might lead to residual confounding.
- Depression was measured using a questionnaire rather than clinical interviews, potentially leading to misclassification.
- Unable to control effectively for exercise or alcohol intake.
Cite This Study
Abas et al. (2002) conducted a cohort in Moderate hypertension (n=2,584). Depression vs. No depression was evaluated on Mortality (HR 1.43, 95% CI 1.03-1.98, p=0.040). Depression was associated with a 43% increased risk of mortality (HR 1.43) in older adults with moderate hypertension, independent of cardiovascular risk factors and cognitive decline.
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