Why the study?
Does pre-existing or incident depression increase the risk of all-cause and cardiovascular mortality in elderly treated hypertensive patients?
Population
6,083 hypertensive patients aged ≥65 years enrolled in the Second Australian National Blood Pressure study
Comparison
Pre-existing or incident depression vs No depression
Design
Cohort
Follow-up
median 10.8 years
Key result
Incident depression in elderly hypertensive patients was associated with increased all-cause mortality compared to those without depression (HR 1.26; 95% CI 1.12-1.41; p<0.001).
Authors
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May support depression screening in elderly hypertensives; leaves open whether treatment reduces mortality.
Cohort (n=6,083)
Yes
Does pre-existing or incident depression increase the risk of all-cause and cardiovascular mortality in elderly treated hypertensive patients?
Hazard Ratio: 1.26 (95% CI 1.12–1.41)
p-value: p=<0.001
In elderly treated hypertensive patients, both pre-existing and incident depression are associated with a significantly increased risk of all-cause and cardiovascular mortality.
Chowdhury et al. (2018) conducted a cohort in Hypertension (n=6,083). Incident depression vs. No depression was evaluated on All-cause mortality (HR 1.26, 95% CI 1.12-1.41, p=<0.001). Incident depression in elderly hypertensive patients was associated with increased all-cause mortality compared to those without depression (HR 1.26; 95% CI 1.12-1.41; p<0.001).