Key result
Angptl2 overexpression in skin epithelial cells accelerated chemically induced squamous cell carcinoma by increasing oxidative stress and decreasing Msh2 expression in a mouse model.
Population
Chemically induced squamous cell carcinoma of the skin mouse model
Comparison
Genetic modification and treatment with the… vs Wild-type mice or untreated K14-Angptl2 Tg mice
Design
Preclinical
Authors
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Angptl2 may mediate inflammation-driven skin carcinogenesis; leaves open its value as a human therapeutic target.
Angptl2 accelerates chemically induced carcinogenesis by increasing oxidative stress and decreasing Msh2 expression, suggesting it as a potential target in premalignant tissue.
Aoi et al. (2013) studied Squamous cell carcinoma of the skin. Angptl2 overexpression (K14-Angptl2 Tg mice) vs. Wild-type mice was evaluated on Oxidative stress and SCC incidence. Angptl2 overexpression in skin epithelial cells accelerated chemically induced squamous cell carcinoma by increasing oxidative stress and decreasing Msh2 expression in a mouse model.
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