October 31, 2011Cancer ResearchOpen Access

Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

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Population

Chemically induced skin squamous cell carcinoma mouse model

Comparison

Angptl2 overexpression or Angptl2 knockout vs Wild-type mice

Design

Preclinical

Authors

JAJun AoiKumamoto University MEMotoyoshi EndoUniversity of Occupational and Environmental Health Japan TKTsuyoshi KadomatsuKumamoto University

Discussion

Member takes

Implication

Angptl2 merits exploration as a therapeutic target in squamous cell carcinoma; hypothesis-generating in this animal model only.

Structured PICO

Population

Chemically induced skin squamous cell carcinoma (SCC) mouse model (wild-type, Angptl2 transgenic, and Angptl2 knockout mice)

Intervention

Angptl2 overexpression (transgenic mice) or Angptl2 knockout

Comparator

Wild-type mice

Outcome

Frequency of carcinogenesis and tumor cell metastasissurrogate

Angptl2 promotes inflammatory carcinogenesis and metastasis in a mouse model of squamous cell carcinoma, suggesting it as a potential therapeutic target.

Cite This Study

Aoi et al. (2011) studied this question.

synapsesocial.com/papers/6a86556dbc4cc88ab58334c3 https://doi.org/10.1158/0008-5472.can-11-1758

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Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider