Key result
Matrix metalloproteinases play a significant role in ventricular remodeling, where extracellular matrix-cell disconnect leads to decreased muscle cell strength, apoptosis, and hypertrophy.
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Metalloproteinases play a significant role in ventricular remodeling and the maintenance of cell-extracellular matrix connections, which are crucial for myocardial function.
Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metalloproteinases, membrane type matrix metalloproteinases, and disintegrin metalloproteinase play a significant role in these processes. The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy.
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Tyagi et al. (2002) conducted a review in Ventricular remodeling. Metalloproteinases was evaluated. Matrix metalloproteinases play a significant role in ventricular remodeling, where extracellular matrix-cell disconnect leads to decreased muscle cell strength, apoptosis, and hypertrophy.
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