Key result
Perioperative use of NSAIDs was associated with more postoperative bleeding complications compared to non-use in patients undergoing total hip arthroplasty.
Why the study?
Does perioperative use of NSAIDs increase postoperative bleeding complications in patients undergoing elective surgery?
Population
165 patients undergoing total hip arthroplasty from 1984 to 1987
Comparison
Perioperative use of nonsteroidal… vs Patients not taking NSAIDs at hospital admission
Design
Cohort
Follow-up
postoperative period
Authors
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Warrants caution with perioperative NSAIDs in hip arthroplasty; observational data leaves open whether avoidance reduces complications.
Cohort (n=165)
Does perioperative use of NSAIDs increase postoperative bleeding complications in patients undergoing elective surgery?
Perioperative use of NSAIDs, particularly those with half-lives longer than 6 hours, is associated with increased postoperative bleeding complications in patients undergoing elective surgery.
Carolyn S. Connelly (1991) conducted a cohort in Total hip arthroplasty (n=165). Nonsteroidal anti-inflammatory drugs (NSAIDs) vs. Not taking NSAIDs was evaluated on Postoperative bleeding complications (gastrointestinal tract bleeding and/or hypotension). Perioperative use of NSAIDs was associated with more postoperative bleeding complications compared to non-use in patients undergoing total hip arthroplasty.
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