Key result
Perioperative use of NSAIDs was not significantly associated with the risk of postoperative myocardial infarction after total joint replacement (OR 0.95; 95% CI 0.5-1.8).
Why the study?
Does perioperative NSAID use reduce postoperative myocardial infarction in patients undergoing total joint replacement?
Population
10,873 patient admissions undergoing total hip or knee replacement between March 3, 2009, and September 1…
Comparison
Perioperative use of nonsteroidal… vs No perioperative NSAID use
Design
Cohort
Follow-up
hospital stay
Authors
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No MI risk signal with perioperative NSAIDs after joint replacement; leaves open need for RCTs to confirm safety.
Cohort (n=10,873)
No
Does perioperative NSAID use reduce postoperative myocardial infarction in patients undergoing total joint replacement?
Odds Ratio: 0.95 (95% CI 0.5–1.8)
Absolute Event Rate: 0.8% vs 1.8%
Brief perioperative use of NSAIDs during total joint replacement is not associated with an increased risk of postoperative myocardial infarction and may significantly reduce hospital length of stay.
Liu et al. (2012) conducted a cohort in Total hip or knee replacement (n=10,873). Nonsteroidal anti-inflammatory drugs (NSAIDs) vs. No NSAIDs was evaluated on Postoperative myocardial infarction (POMI) (OR 0.95, 95% CI 0.5-1.8). Perioperative use of NSAIDs was not significantly associated with the risk of postoperative myocardial infarction after total joint replacement (OR 0.95; 95% CI 0.5-1.8).
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