What is the clinical evidence from this study?

Intervention: QT correction formulas (Bazzett, Fridericia, Mitchell, Hodges, Van der Water, Framingham). Primary outcome: Correlation of QT correction formulas to heart rate.

What question did this study set out to answer?

The study aims to establish reference range values for ECG parameters and identify the most effective QT correction formulas for different rodent species.

June 1, 2019Pesquisa Veterinária BrasileiraOpen Access

Non-invasive ECG recording and QT interval correction assessment in anesthetized rats and mice

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Key result

Hodges' formula was the most effective method for QT correction in anesthetized rats and mice, whereas Bazett's and Fridericia formulas were ineffective.

Why the study?

A lack of standardized reference values and QT correction formulas for different rodent species and lineages challenges ECG interpretation.

Key Points

The study aims to establish reference range values for ECG parameters and identify the most effective QT correction formulas for different rodent species.
Conducted ECG recording in 40 anesthetized rodents (10 Wistar rats, 30 mice) using isoflurane anesthesia.
Employed a six-channel non-invasive electrocardiograph for data collection.
Calculated QT interval correction using multiple formulas (Hodges, Bazett, Fridericia, etc.) and assessed their correlation with heart rate.
Hodges' formula showed the highest correlation with heart rate for QT correction (R=0.85, p<0.001).
Normal range values for ECG parameters were established for all rodent species studied.
Bazett’s and Fridericia's formulas were found ineffective in the tested rodents.

Structured PICO

Population

40 rodents (10 Wistar rats, 10 Swiss mice, 10 C57BL/6 mice, and 10 FVB/NJ mice) undergoing non-invasive ECG recording under isoflurane anesthesia.

Exposure

Non-invasive ECG recording under isoflurane anesthesia and QT correction using Bazzett, Fridericia, Mitchell, Hodges, Van der Water and Framingham formulas

Outcome

Establishment of normal range values for ECG parameters and determination of the QT formula with higher correlation to heart rate (HR)surrogate

Hodges' formula is the most suitable for QT correction in rodents, providing a standardized method for experimental cardiac electrophysiology studies.

Discussion

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Implication

May aid rodent ECG standardization in electrophysiology models; leaves open clinical translation pending human validation studies.

Cite This Study

Botelho et al. (2019) studied this question. QT correction formulas (Bazzett, Fridericia, Mitchell, Hodges, Van der Water, Framingham) was evaluated on Correlation of QT correction formulas to heart rate. Hodges' formula was the most effective method for QT correction in anesthetized rats and mice, whereas Bazett's and Fridericia formulas were ineffective.

synapsesocial.com/papers/6a63f6c394d8bae735b37d50 https://doi.org/10.1590/1678-6160-pvb-6029

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Non-invasive ECG recording and QT interval correction assessment in anesthetized rats and mice

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Non-invasive ECG recording and QT interval correction assessment in anesthetized rats and mice

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Also Consider