Key result
Panic disorder was associated with significantly higher nighttime QT interval variability compared with normal controls, indicating blunted diurnal changes in ventricular repolarization lability.
Why the study?
Is QT interval variability during sleep increased in patients with panic disorder compared to normal adults?
Population
22 patients with panic disorder and 32 normal adult controls (n=54)
Comparison
24-hour electrocardiogram recording vs Normal adult controls
Design
Case-control
Follow-up
24-hour
Authors
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Diurnal QTV differences in anxiety may aid risk stratification; leaves open prospective validation for SCD prediction.
Case-Control (n=54)
Is QT interval variability during sleep increased in patients with panic disorder compared to normal adults?
Patients with panic disorder exhibit significantly higher QT variability during sleep, indicating blunted diurnal changes in ventricular repolarization lability that may relate to increased cardiac mortality risk.
Yeragani et al. (2002) conducted a case-control in Panic disorder (n=54). Panic disorder vs. Normal adults was evaluated on QT interval variability (QTV) measures at nighttime. Panic disorder was associated with significantly higher nighttime QT interval variability compared with normal controls, indicating blunted diurnal changes in ventricular repolarization lability.
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