Key result
Over a mean interval of 3.0 years, Parkinson's disease patients showed a significant decline in early heart to mediastinum ratio on 123I-MIBG scintigraphy from 1.83 to 1.69 (p<0.001).
Population
70 patients with Parkinson's disease who underwent 123I-MIBG myocardial scintigraphy twice or more
Design
Cohort
Follow-up
mean 3.0 years
Authors
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Serial MIBG may track cardiac denervation progression in PD; leaves open prognostic value and management implications.
Cohort (n=70)
Absolute Event Rate: 1.69% vs 1.83%
p-value: p=<0.001
Longitudinal 123I-MIBG myocardial scintigraphy in Parkinson's disease reveals progressive decline in cardiac sympathetic innervation, with a subgroup of patients showing normal/mildly low initial uptake associated with female sex, younger onset, and slower progression.
Tsujikawa et al. (2015) conducted a cohort in Parkinson's disease (n=70). Time (disease progression) vs. Baseline was evaluated on Early heart to mediastinum (H/M) ratio (p=<0.001). Over a mean interval of 3.0 years, Parkinson's disease patients showed a significant decline in early heart to mediastinum ratio on 123I-MIBG scintigraphy from 1.83 to 1.69 (p<0.001).
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