Key result
Parkinson's disease linked to reduced HRV and greater BP drops during tilt testing.
Why the study?
Patients with Parkinson's disease show reduced myocardial 123I-MIBG uptake, which may affect cardiovascular autonomic regulation, but the correlation was unclear.
Does myocardial 123I-MIBG uptake correlate with cardiovascular autonomic function in patients with Parkinson's disease?
Cross-Sectional (n=100)
Does myocardial 123I-MIBG uptake correlate with cardiovascular autonomic function in patients with Parkinson's disease?
p-value: p=0.005
Reduced myocardial MIBG accumulation in Parkinson's disease correlates with blood pressure dysregulation, suggesting orthostatic hypotension is mainly caused by sympathetic postganglionic degeneration.
May inform orthostatic hypotension risk stratification in PD; hypothesis-generating and should not yet change practice.
Introduction. Patients with Parkinson's disease (PD) showed reduced myocardial (123)I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD. Methods. We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4 ± 7.8 years; duration 5.5 ± 5.9 years). Autonomic function tests were also performed in 50 healthy controls (66.5 ± 8.9 years). As HRV parameters, a high-frequency power (HF, 0.15-0.4 Hz), a low-frequency power (LF, 0.04-0.15 Hz), and LF/HF ratio were used. Results. Our PD patients had a significant reduction in LF and HF compared with the controls (P = 0.005 and P = 0.01). In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P = 0.02 and P = 0.02). The washout rate of MIBG was negatively correlated with blood pressure changes during HUT. Conclusion. Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation. Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration.
No takes yet. Share an insight, caveat, or question.
Katagiri et al. (2015) conducted a cross-sectional in Parkinson's disease (n=100). Parkinson's disease vs. Healthy controls was evaluated on Heart rate variability (LF and HF) and blood pressure falls during head-up tilt test (p=0.005). Parkinson's disease was associated with significantly reduced low-frequency (P=0.005) and high-frequency (P=0.01) heart rate variability and greater blood pressure falls during tilt testing.